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Xenical (orlisat), the only prescription anti-obesity medication that blocks the absorption of dietary fat, one of the commonly accepted causes of obesity. Xenical, unlike other anti-obesity medications that work in the brain or nervous system to suppress appetite, is a safe non-systemically acting medication that works specifically in the digestive tract to prevent the absorption of approximately 30 per cent of dietary fat. The non-digested fat is excreted by the body. The fat-blocking action of Xenical not only helps patients decrease weight and keep it off, it has also been shown to improve obesity-related conditions including high cholesterol, diabetes (insulin and blood sugar) and high blood pressure. Xenical is indicated for weight loss and weight maintenance when used in conjunction with a modest calorie-reduced diet. Xenical is the most comprehensively studied anti-obesity medication ever, with more than 7,000 patients world-wide having participated in clinical studies. Currently, Xenical is available in 19 countries around the world. Pooled data from clinical trials on Xenical show that three times as many patients taking Xenical in combination with a mild calorie-reduced diet lost more than 10 per cent of their initial body weight versus diet alone. Two times as many patients lost more than five per cent of their initial body weight compared to diet alone. Weight loss is seen within two weeks of initiating therapy. In the most recently published study on Xenical in the Journal of the American Medical Association, patients lost on average 19.5 pounds (8.76 kilos) in the first year versus 12.8 pounds (5.81 kilos) on placebo. In the second year, when calorie intake was increased and the goal was to maintain lost weight, those patients on placebo regained 63 per cent of their lost weight, versus only a 35 per cent regain for those on Xenical. The authors noted, however, that 34 per cent of patients on Xenical for the full two years maintained a weight loss of more than 10 per cent of initial body weight compared with only 17.5 per cent who received placebo for the full two years. "Xenical-treated patients typically lose at least five to 10 per cent of body weight over the first year of treatment," said Dr. Lawrence Leiter, a professor of medicine at the University of Toronto, director of the Lipid Clinic at St. Michael's Hospital in Toronto and a clinical investigator in Xenical clinical trials. "We know that weight loss in this range has a positive impact on obesity-related risk factors such as high blood pressure, type II diabetes and cholesterol abnormalities. "What's encouraging is that clinical trials with Xenical have demonstrated this benefit. This is consistent with the emphasis on weight loss as a way to achieve improved health outcomes." Patients treated with Xenical have shown measurable improvements in total and low-density lipoproteins (LDL) or bad cholesterol, systolic and diastolic blood pressure, concentrations of fasting glucose (blood sugar) and insulin. In a study published last year, 43.2 per cent of Xenical-treated patients with type II diabetes reduced the amount of diabetes medication they required versus only 28.9 per cent in the non-treatment group and 11.7 per cent of the Xenical-treated group completely discontinued their use of diabetes medication. Xenical is a blue, 120 mg capsule that is taken three times daily with meals. A patient's total daily food intake will vary based on gender and current weight, but could be around 1,800 to 2,700 calories a day or higher -- significantly more than fad diets which often contain 1,200 or less calories a day. Meals eaten with Xenical can contain up to 30 per cent of calories from fat. Click Here to Order Xenical Online.
Article from the Associated Press:
FDA Approves Xenical,
New Fat-Blocking Drug XENICAL
Dieters today won the first medication that does more than suppress
appetite, a pill that blocks absorption of almost a third of the
fat they eat. The Food and Drug Administration approved Xenical, 2 1/2 years after Hoffman-La Roche Inc. first
sought to sell Xenical, a delay largely caused by questions
about whether Xenical might contribute to breast cancer.
But the FDA ultimately decided that Xenical
was safe, approving it by prescription only for the seriously
obese— not casual dieters who just want to shed five or 10
pounds. Xenical has been long-awaited by obesity
experts, who say they need new alternatives after the ill-fated
Redux and fen-phen were banned in 1997 over concerns that damaged
dieters' hearts. The only prescription weight-loss drugs left
on the U.S. market are appetite suppressors. Xenical,
known chemically as orlistat, works differently, blocking absorption
of 30 percent of the fat a person eats. That doesn't mean people
can feast on cheeseburgers and still lose weight, experts caution.
Dieters would take one capsule with each main meal, up to three
daily, that contain up to 30 percent fat. That means that if a
dieter ingested 60 grams of fat a day, he or she would actually
absorb only 40 grams and Xenical would help the other 20 be excreted.
In one study, 57 percent of patients treated with Xenical plus fairly low-fat diet lost at least 5 percent
of their baseline body weight, vs. just 31 percent of patients
who took a dummy pill plus the diet. Click Here
to Order Xenical Online.